Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo

Neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau are a histopathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Hyperphosphorylation of tau is responsible for its loss of normal physiological function, gain of toxicity and its aggregation to form NFTs. Injecti...

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Detalles Bibliográficos
Autores principales: Miao, Jin, Shi, Ruirui, Li, Longfei, Chen, Feng, Zhou, Yan, Tung, Yunn Chyn, Hu, Wen, Gong, Cheng-Xin, Iqbal, Khalid, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411797/
https://www.ncbi.nlm.nih.gov/pubmed/30890929
http://dx.doi.org/10.3389/fnagi.2019.00034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411797/
https://www.ncbi.nlm.nih.gov/pubmed/30890929
http://dx.doi.org/10.3389/fnagi.2019.00034

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