Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m(1)A) and 3-methylcytidine (m(3)C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion. In vivo study...

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Detalles Bibliográficos
Autores principales: Chen, Zhuojia, Qi, Meijie, Shen, Bin, Luo, Guanzheng, Wu, Yingmin, Li, Jiexin, Lu, Zhike, Zheng, Zhong, Dai, Qing, Wang, Hongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411830/
https://www.ncbi.nlm.nih.gov/pubmed/30541109
http://dx.doi.org/10.1093/nar/gky1250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411830/
https://www.ncbi.nlm.nih.gov/pubmed/30541109
http://dx.doi.org/10.1093/nar/gky1250

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