A network of eIF2β interactions with eIF1 and Met-tRNA(i) promotes accurate start codon selection by the translation preinitiation complex

In translation initiation, a 43S preinitiation complex (PIC) containing eIF1 and a ternary complex (TC) of GTP-bound eIF2 and Met-RNA(i) scans the mRNA for the start codon. AUG recognition triggers eIF1 release and rearrangement from an open PIC conformation to a closed state with more tightly-bound...

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Detalles Bibliográficos
Autores principales: Thakur, Anil, Marler, Laura, Hinnebusch, Alan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411837/
https://www.ncbi.nlm.nih.gov/pubmed/30576497
http://dx.doi.org/10.1093/nar/gky1274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411837/
https://www.ncbi.nlm.nih.gov/pubmed/30576497
http://dx.doi.org/10.1093/nar/gky1274

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