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A network of eIF2β interactions with eIF1 and Met-tRNA(i) promotes accurate start codon selection by the translation preinitiation complex
In translation initiation, a 43S preinitiation complex (PIC) containing eIF1 and a ternary complex (TC) of GTP-bound eIF2 and Met-RNA(i) scans the mRNA for the start codon. AUG recognition triggers eIF1 release and rearrangement from an open PIC conformation to a closed state with more tightly-bound...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411837/ https://www.ncbi.nlm.nih.gov/pubmed/30576497 http://dx.doi.org/10.1093/nar/gky1274 |