Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease

The most common presentation of early onset Alzheimer's disease (EOAD – defined as symptom onset <65 years) is with progressive episodic memory impairment – amnestic or typical Alzheimer's disease (tAD). However, EOAD is notable for its phenotypic heterogeneity, with posterior cortical...

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Autores principales: Parker, Thomas D., Slattery, Catherine F., Yong, Keir X.X., Nicholas, Jennifer M., Paterson, Ross W., Foulkes, Alexander J.M., Malone, Ian B., Thomas, David L., Cash, David M., Crutch, Sebastian J., Fox, Nick C., Schott, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411912/
https://www.ncbi.nlm.nih.gov/pubmed/30558867
http://dx.doi.org/10.1016/j.nicl.2018.101632
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author Parker, Thomas D.
Slattery, Catherine F.
Yong, Keir X.X.
Nicholas, Jennifer M.
Paterson, Ross W.
Foulkes, Alexander J.M.
Malone, Ian B.
Thomas, David L.
Cash, David M.
Crutch, Sebastian J.
Fox, Nick C.
Schott, Jonathan M.
author_facet Parker, Thomas D.
Slattery, Catherine F.
Yong, Keir X.X.
Nicholas, Jennifer M.
Paterson, Ross W.
Foulkes, Alexander J.M.
Malone, Ian B.
Thomas, David L.
Cash, David M.
Crutch, Sebastian J.
Fox, Nick C.
Schott, Jonathan M.
author_sort Parker, Thomas D.
collection PubMed
description The most common presentation of early onset Alzheimer's disease (EOAD – defined as symptom onset <65 years) is with progressive episodic memory impairment – amnestic or typical Alzheimer's disease (tAD). However, EOAD is notable for its phenotypic heterogeneity, with posterior cortical atrophy (PCA) – characterised by prominent higher-order visual processing deficits and relative sparing of episodic memory – the second most common canonical phenotype. The hippocampus, which comprises a number of interconnected anatomically and functionally distinct subfields, is centrally involved in Alzheimer's disease and is a crucial mediator of episodic memory. The extent to which volumes of individual hippocampal subfields differ between different phenotypes in EOAD is unclear. The aim of this analysis was to investigate the hypothesis that patients with a PCA phenotype will exhibit differences in specific hippocampal subfield volumes compared to tAD. We studied 63 participants with volumetric T1-weighted MRI performed on the same 3T scanner: 39 EOAD patients [27 with tAD and 12 with PCA] and 24 age-matched controls. Volumetric estimates of the following hippocampal subfields for each participant were obtained using Freesurfer version 6.0: CA1, CA2/3, CA4, presubiculum, subiculum, hippocampal tail, parasubiculum, the molecular and granule cell layers of the dentate gryus (GCMLDG), the molecular layer, and the hippocampal amygdala transition area (HATA). Linear regression analyses comparing mean hippocampal subfield volumes between groups, adjusting for age, sex and head size, were performed. Using a Bonferonni-corrected p-value of p < 0.0025, compared to controls, tAD was associated with atrophy in all hippocampal regions, except the parasubiculum. In PCA patients compared to controls, the strongest evidence for volume loss was in the left presubiclum, right subiculum, right GCMLDG, right molecular layer and the right HATA. Compared to PCA, patients with tAD had strong evidence for smaller volumes in left CA1 and left hippocampal tail. In conclusion, these data provide evidence that hippocampal subfield volumes differ in different phenotypes of EOAD.
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spelling pubmed-64119122019-03-22 Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease Parker, Thomas D. Slattery, Catherine F. Yong, Keir X.X. Nicholas, Jennifer M. Paterson, Ross W. Foulkes, Alexander J.M. Malone, Ian B. Thomas, David L. Cash, David M. Crutch, Sebastian J. Fox, Nick C. Schott, Jonathan M. Neuroimage Clin Article The most common presentation of early onset Alzheimer's disease (EOAD – defined as symptom onset <65 years) is with progressive episodic memory impairment – amnestic or typical Alzheimer's disease (tAD). However, EOAD is notable for its phenotypic heterogeneity, with posterior cortical atrophy (PCA) – characterised by prominent higher-order visual processing deficits and relative sparing of episodic memory – the second most common canonical phenotype. The hippocampus, which comprises a number of interconnected anatomically and functionally distinct subfields, is centrally involved in Alzheimer's disease and is a crucial mediator of episodic memory. The extent to which volumes of individual hippocampal subfields differ between different phenotypes in EOAD is unclear. The aim of this analysis was to investigate the hypothesis that patients with a PCA phenotype will exhibit differences in specific hippocampal subfield volumes compared to tAD. We studied 63 participants with volumetric T1-weighted MRI performed on the same 3T scanner: 39 EOAD patients [27 with tAD and 12 with PCA] and 24 age-matched controls. Volumetric estimates of the following hippocampal subfields for each participant were obtained using Freesurfer version 6.0: CA1, CA2/3, CA4, presubiculum, subiculum, hippocampal tail, parasubiculum, the molecular and granule cell layers of the dentate gryus (GCMLDG), the molecular layer, and the hippocampal amygdala transition area (HATA). Linear regression analyses comparing mean hippocampal subfield volumes between groups, adjusting for age, sex and head size, were performed. Using a Bonferonni-corrected p-value of p < 0.0025, compared to controls, tAD was associated with atrophy in all hippocampal regions, except the parasubiculum. In PCA patients compared to controls, the strongest evidence for volume loss was in the left presubiclum, right subiculum, right GCMLDG, right molecular layer and the right HATA. Compared to PCA, patients with tAD had strong evidence for smaller volumes in left CA1 and left hippocampal tail. In conclusion, these data provide evidence that hippocampal subfield volumes differ in different phenotypes of EOAD. Elsevier 2018-12-11 /pmc/articles/PMC6411912/ /pubmed/30558867 http://dx.doi.org/10.1016/j.nicl.2018.101632 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parker, Thomas D.
Slattery, Catherine F.
Yong, Keir X.X.
Nicholas, Jennifer M.
Paterson, Ross W.
Foulkes, Alexander J.M.
Malone, Ian B.
Thomas, David L.
Cash, David M.
Crutch, Sebastian J.
Fox, Nick C.
Schott, Jonathan M.
Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
title Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
title_full Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
title_fullStr Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
title_full_unstemmed Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
title_short Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease
title_sort differences in hippocampal subfield volume are seen in phenotypic variants of early onset alzheimer's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411912/
https://www.ncbi.nlm.nih.gov/pubmed/30558867
http://dx.doi.org/10.1016/j.nicl.2018.101632
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