Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux

Cystic fibrosis is a disease caused by defective function of a chloride channel coupled to a blockade of autophagic flux. It has been proposed to use synthetic chloride transporters as pharmacological agents to compensate insufficient chloride fluxes. Here, we report that such chloride anionophores...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shaoyi, Wang, Yan, Xie, Wei, Howe, Ethan N. W., Busschaert, Nathalie, Sauvat, Allan, Leduc, Marion, Gomes-da-Silva, Lígia C., Chen, Guo, Martins, Isabelle, Deng, Xiaxing, Maiuri, Luigi, Kepp, Oliver, Soussi, Thierry, Gale, Philip A., Zamzami, Naoufal, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411943/
https://www.ncbi.nlm.nih.gov/pubmed/30858361
http://dx.doi.org/10.1038/s41419-019-1474-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411943/
https://www.ncbi.nlm.nih.gov/pubmed/30858361
http://dx.doi.org/10.1038/s41419-019-1474-8

Ejemplares similares