Discovery of NV-5138, the first selective Brain mTORC1 activator

The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1 activation. The cytoplasmic proteins Sestrin1 and...

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Detalles Bibliográficos
Autores principales: Sengupta, Shomit, Giaime, Emilie, Narayan, Sridhar, Hahm, Seung, Howell, Jessica, O’Neill, David, Vlasuk, George P., Saiah, Eddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412019/
https://www.ncbi.nlm.nih.gov/pubmed/30858438
http://dx.doi.org/10.1038/s41598-019-40693-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412019/
https://www.ncbi.nlm.nih.gov/pubmed/30858438
http://dx.doi.org/10.1038/s41598-019-40693-5

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