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Discovery of NV-5138, the first selective Brain mTORC1 activator
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1 activation. The cytoplasmic proteins Sestrin1 and...
Autores principales: | Sengupta, Shomit, Giaime, Emilie, Narayan, Sridhar, Hahm, Seung, Howell, Jessica, O’Neill, David, Vlasuk, George P., Saiah, Eddine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412019/ https://www.ncbi.nlm.nih.gov/pubmed/30858438 http://dx.doi.org/10.1038/s41598-019-40693-5 |
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