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The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency

USP37 is a deubiquitinase (DUB) with roles in the regulation of DNA damage repair and the cohesion of sister chromatids during mitosis. USP37 contains a unique insert of three ubiquitin interacting motifs (UIMs) within its catalytic DUB domain. We investigated the role of the three UIMs in the abili...

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Detalles Bibliográficos
Autores principales: Manczyk, Noah, Veggiani, Gianluca, Teyra, Joan, Strilchuk, Amy W., Sidhu, Sachdev S., Sicheri, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412040/
https://www.ncbi.nlm.nih.gov/pubmed/30858488
http://dx.doi.org/10.1038/s41598-019-40815-z