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Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
Six 1′,5′-anhydrohexitol uridine triphosphates were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of their bases. An improved method for obtaining such 5-substituted hexitol nucleosides and nucleotides is described. The incorporation profile of the nucle...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412122/ https://www.ncbi.nlm.nih.gov/pubmed/30698800 http://dx.doi.org/10.1093/nar/gkz008 |