Cargando…

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases

Six 1′,5′-anhydrohexitol uridine triphosphates were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of their bases. An improved method for obtaining such 5-substituted hexitol nucleosides and nucleotides is described. The incorporation profile of the nucle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Renders, Marleen, Dumbre, Shrinivas, Abramov, Mikhail, Kestemont, Donaat, Margamuljana, Lia, Largy, Eric, Cozens, Christopher, Vandenameele, Julie, Pinheiro, Vitor B, Toye, Dominique, Frère, Jean-Marie, Herdewijn, Piet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412122/ https://www.ncbi.nlm.nih.gov/pubmed/30698800 http://dx.doi.org/10.1093/nar/gkz008

Ejemplares similares

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor
por: Eremeeva, Elena, et al.
Publicado: (2019)

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties
por: Maiti, Mohitosh, et al.
Publicado: (2015)

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
por: Yang, Hui, et al.
Publicado: (2023)

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid
por: Hajjar, Mohammad, et al.
Publicado: (2022)

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
por: Wolk, Steven K., et al.
Publicado: (2015)

Thermal stabilisation of the short DNA duplexes by acridine-4-carboxamide derivatives
por: Kostelansky, Filip, et al.
Publicado: (2022)

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
por: Kumar, Pawan, et al.
Publicado: (2020)

Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity
por: Alves Ferreira-Bravo, Irani, et al.
Publicado: (2015)

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis
por: Rietmeyer, Lauriane, et al.
Publicado: (2022)

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif
por: Schofield, Peter, et al.
Publicado: (2023)

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
por: Adelfinskaya, O., et al.
Publicado: (2007)

Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
por: Réblová, Kamila, et al.
Publicado: (2007)

Components of variance in transcriptomics based on electrophoretic separation of cDNA fragments (cDNA-AFLP)
por: Weiberg, Arne, et al.
Publicado: (2009)

RNA pseudoknots
por: Westhof, Eric, et al.
Publicado: (1992)

Isometric artifacts from polymerase chain reaction‐massively parallel sequencing analysis of short tandem repeat loci: An emerging issue from a new technology?
por: Zupanič Pajnič, Irena, et al.
Publicado: (2022)

Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization
por: Kempeneers, Veerle, et al.
Publicado: (2005)

Random-sequence genetic oligomer pools display an innate potential for ligation and recombination
por: Mutschler, Hannes, et al.
Publicado: (2018)

Cellulose Conversion Into Hexitols and Glycols in Water: Recent Advances in Catalyst Development
por: Manaenkov, Oleg V., et al.
Publicado: (2019)

Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA
por: Price, Nathan E., et al.
Publicado: (2015)

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity
por: Prakash, Thazha P., et al.
Publicado: (2015)

Outwitting EF-Tu and the ribosome: translation with d-amino acids
por: Achenbach, John, et al.
Publicado: (2015)

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs
por: Ohkubo, Akihiro, et al.
Publicado: (2015)

Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-free click chemistry
por: Someya, Tatsuhiko, et al.
Publicado: (2015)

Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
por: Shan, Chan, et al.
Publicado: (2015)

Linking two DNA duplexes with a rigid linker for DNA nanotechnology
por: Tashiro, Ryu, et al.
Publicado: (2015)

The unusual and dynamic character of PX-DNA
por: Niu, Dong, et al.
Publicado: (2015)

Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation
por: Wang, Peng, et al.
Publicado: (2015)

DNA–DNA kissing complexes as a new tool for the assembly of DNA nanostructures
por: Barth, Anna, et al.
Publicado: (2016)

Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
por: Shopsowitz, Kevin E., et al.
Publicado: (2016)

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta
por: Choi, Jung-Suk, et al.
Publicado: (2016)

Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding
por: Selvam, Sangeetha, et al.
Publicado: (2016)

Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents
por: Huang, Wei-Chun, et al.
Publicado: (2015)

Thermodynamic properties of water molecules in the presence of cosolute depend on DNA structure: a study using grid inhomogeneous solvation theory
por: Nakano, Miki, et al.
Publicado: (2015)

Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization
por: Larsen, Aaron T., et al.
Publicado: (2015)

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
por: Yunn, Na-Oh, et al.
Publicado: (2015)

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative
por: Scuotto, Maria, et al.
Publicado: (2015)

Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts
por: Kusano, Shuhei, et al.
Publicado: (2015)

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity
por: Virgilio, Antonella, et al.
Publicado: (2015)

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
por: Wan, W. Brad, et al.
Publicado: (2014)

Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA
por: Hashiya, Fumitaka, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_mej3vciv0ljklnghnvt1re9k36