Bayesian inference of origin firing time distributions, origin interference and licencing probabilities from Next Generation Sequencing data

DNA replication is a stochastic process with replication forks emanating from multiple replication origins. The origins must be licenced in G1, and the replisome activated at licenced origins in order to generate bi-directional replication forks in S-phase. Differential firing times lead to origin i...

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Detalles Bibliográficos
Autores principales: Bazarova, Alina, Nieduszynski, Conrad A, Akerman, Ildem, Burroughs, Nigel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412128/
https://www.ncbi.nlm.nih.gov/pubmed/30859196
http://dx.doi.org/10.1093/nar/gkz094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412128/
https://www.ncbi.nlm.nih.gov/pubmed/30859196
http://dx.doi.org/10.1093/nar/gkz094

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