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Bayesian inference of origin firing time distributions, origin interference and licencing probabilities from Next Generation Sequencing data
DNA replication is a stochastic process with replication forks emanating from multiple replication origins. The origins must be licenced in G1, and the replisome activated at licenced origins in order to generate bi-directional replication forks in S-phase. Differential firing times lead to origin i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412128/ https://www.ncbi.nlm.nih.gov/pubmed/30859196 http://dx.doi.org/10.1093/nar/gkz094 |