Targeting the Iron-Response Elements of the mRNAs for the Alzheimer’s Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity

The therapeutic value of inhibiting translation of the amyloid precursor protein (APP) offers the possibility to reduce neurotoxic amyloid formation, particularly in cases of familial Alzheimer’s disease (AD) caused by APP gene duplications (Dup–APP) and in aging Down syndrome individuals. APP mRNA...

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Detalles Bibliográficos
Autores principales: Rogers, Jack T., Xia, Ning, Wong, Angela, Bakshi, Rachit, Cahill, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412244/
https://www.ncbi.nlm.nih.gov/pubmed/30823541
http://dx.doi.org/10.3390/ijms20040994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412244/
https://www.ncbi.nlm.nih.gov/pubmed/30823541
http://dx.doi.org/10.3390/ijms20040994

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