High-Throughput Virtual Screening, Molecular Dynamics Simulation, and Enzyme Kinetics Identified ZINC84525623 as a Potential Inhibitor of NDM-1

The bacteria expressing New Delhi Metallo-β-lactamase-1 (NDM-1) can hydrolyze all β-lactam antibiotics including carbapenems, causing multi-drug resistance. The worldwide emergence and dissemination of gene bla(NDM-1) (produces NDM-1) in hospital and community settings, rising problems for public he...

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Detalles Bibliográficos
Autores principales: Rehman, Md Tabish, AlAjmi, Mohamed F, Hussain, Afzal, Rather, Gulam Mohmad, Khan, Meraj A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412273/
https://www.ncbi.nlm.nih.gov/pubmed/30769822
http://dx.doi.org/10.3390/ijms20040819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412273/
https://www.ncbi.nlm.nih.gov/pubmed/30769822
http://dx.doi.org/10.3390/ijms20040819

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