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High-Throughput Virtual Screening, Molecular Dynamics Simulation, and Enzyme Kinetics Identified ZINC84525623 as a Potential Inhibitor of NDM-1

The bacteria expressing New Delhi Metallo-β-lactamase-1 (NDM-1) can hydrolyze all β-lactam antibiotics including carbapenems, causing multi-drug resistance. The worldwide emergence and dissemination of gene bla(NDM-1) (produces NDM-1) in hospital and community settings, rising problems for public he...

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Detalles Bibliográficos
Autores principales:	Rehman, Md Tabish, AlAjmi, Mohamed F, Hussain, Afzal, Rather, Gulam Mohmad, Khan, Meraj A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412273/ https://www.ncbi.nlm.nih.gov/pubmed/30769822 http://dx.doi.org/10.3390/ijms20040819

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