Increased TGF-β and BMP Levels and Improved Chondrocyte-Specific Marker Expression In Vitro under Cartilage-Specific Physiological Osmolarity

During standard expansion culture (i.e., plasma osmolarity, 280 mOsm) human articular chondrocytes dedifferentiate, making them inappropriate for autologous chondrocyte implantation to treat cartilage defects. Increasing the osmolarity of culture media to physiological osmolarity levels of cartilage...

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Detalles Bibliográficos
Autores principales: Tan Timur, Ufuk, Caron, Marjolein, van den Akker, Guus, van der Windt, Anna, Visser, Jenny, van Rhijn, Lodewijk, Weinans, Harrie, Welting, Tim, Emans, Pieter, Jahr, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412363/
https://www.ncbi.nlm.nih.gov/pubmed/30781744
http://dx.doi.org/10.3390/ijms20040795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412363/
https://www.ncbi.nlm.nih.gov/pubmed/30781744
http://dx.doi.org/10.3390/ijms20040795

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