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Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years

Nitric oxide (NO) facilitates anti-atherosclerotic effects. Vegetables are a major source of dietary nitrate. Experimental data indicates that dietary nitrate can significantly reduce major risk factors for atherosclerosis and subsequent cardiovascular disease (CVD), as nitrate can be metabolized to...

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Autores principales: Jackson, Jacklyn K., Patterson, Amanda J., MacDonald-Wicks, Lesley K., Forder, Peta M., Blekkenhorst, Lauren C., Bondonno, Catherine P., Hodgson, Jonathan M., Ward, Natalie C., Holder, Carl, Oldmeadow, Christopher, Byles, Julie E., McEvoy, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412377/
https://www.ncbi.nlm.nih.gov/pubmed/30678264
http://dx.doi.org/10.3390/nu11020240
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author Jackson, Jacklyn K.
Patterson, Amanda J.
MacDonald-Wicks, Lesley K.
Forder, Peta M.
Blekkenhorst, Lauren C.
Bondonno, Catherine P.
Hodgson, Jonathan M.
Ward, Natalie C.
Holder, Carl
Oldmeadow, Christopher
Byles, Julie E.
McEvoy, Mark A.
author_facet Jackson, Jacklyn K.
Patterson, Amanda J.
MacDonald-Wicks, Lesley K.
Forder, Peta M.
Blekkenhorst, Lauren C.
Bondonno, Catherine P.
Hodgson, Jonathan M.
Ward, Natalie C.
Holder, Carl
Oldmeadow, Christopher
Byles, Julie E.
McEvoy, Mark A.
author_sort Jackson, Jacklyn K.
collection PubMed
description Nitric oxide (NO) facilitates anti-atherosclerotic effects. Vegetables are a major source of dietary nitrate. Experimental data indicates that dietary nitrate can significantly reduce major risk factors for atherosclerosis and subsequent cardiovascular disease (CVD), as nitrate can be metabolized to produce NO via the nitrate-nitrite-NO pathway. The purpose of this study was to prospectively investigate the association between habitual dietary nitrate intakes and the incidence of self-reported CVD-related complications within a representative sample of middle-aged Australian women (1946–1951 cohort of the Australian Longitudinal Study on Women’s Health). Women free from disease at baseline who had completed the food frequency questionnaire data were included. Generalized estimating equations were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) across quartiles for nitrate intakes. Of the 5324 women included for analysis, there were 1951 new cases of CVD-related complications over 15-years of follow-up. Women reporting higher total dietary nitrate intakes (Q4 > 78.2 mg/day) and vegetable nitrate intakes (Q4 > 64.4 mg/day) were 25% and 27% reduced risk of developing CVD-related complications respectively, compared with women reporting low total (Q1 < 45.5 mg/day) and vegetable nitrate intakes (Q1 < 34.8 mg/day). Our findings were consistent with other observational data indicating that dietary nitrate may explain some of the cardiovascular benefits of vegetable consumption.
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spelling pubmed-64123772019-03-29 Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years Jackson, Jacklyn K. Patterson, Amanda J. MacDonald-Wicks, Lesley K. Forder, Peta M. Blekkenhorst, Lauren C. Bondonno, Catherine P. Hodgson, Jonathan M. Ward, Natalie C. Holder, Carl Oldmeadow, Christopher Byles, Julie E. McEvoy, Mark A. Nutrients Article Nitric oxide (NO) facilitates anti-atherosclerotic effects. Vegetables are a major source of dietary nitrate. Experimental data indicates that dietary nitrate can significantly reduce major risk factors for atherosclerosis and subsequent cardiovascular disease (CVD), as nitrate can be metabolized to produce NO via the nitrate-nitrite-NO pathway. The purpose of this study was to prospectively investigate the association between habitual dietary nitrate intakes and the incidence of self-reported CVD-related complications within a representative sample of middle-aged Australian women (1946–1951 cohort of the Australian Longitudinal Study on Women’s Health). Women free from disease at baseline who had completed the food frequency questionnaire data were included. Generalized estimating equations were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) across quartiles for nitrate intakes. Of the 5324 women included for analysis, there were 1951 new cases of CVD-related complications over 15-years of follow-up. Women reporting higher total dietary nitrate intakes (Q4 > 78.2 mg/day) and vegetable nitrate intakes (Q4 > 64.4 mg/day) were 25% and 27% reduced risk of developing CVD-related complications respectively, compared with women reporting low total (Q1 < 45.5 mg/day) and vegetable nitrate intakes (Q1 < 34.8 mg/day). Our findings were consistent with other observational data indicating that dietary nitrate may explain some of the cardiovascular benefits of vegetable consumption. MDPI 2019-01-22 /pmc/articles/PMC6412377/ /pubmed/30678264 http://dx.doi.org/10.3390/nu11020240 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jackson, Jacklyn K.
Patterson, Amanda J.
MacDonald-Wicks, Lesley K.
Forder, Peta M.
Blekkenhorst, Lauren C.
Bondonno, Catherine P.
Hodgson, Jonathan M.
Ward, Natalie C.
Holder, Carl
Oldmeadow, Christopher
Byles, Julie E.
McEvoy, Mark A.
Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years
title Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years
title_full Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years
title_fullStr Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years
title_full_unstemmed Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years
title_short Vegetable Nitrate Intakes Are Associated with Reduced Self-Reported Cardiovascular-Related Complications within a Representative Sample of Middle-Aged Australian Women, Prospectively Followed up for 15 Years
title_sort vegetable nitrate intakes are associated with reduced self-reported cardiovascular-related complications within a representative sample of middle-aged australian women, prospectively followed up for 15 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412377/
https://www.ncbi.nlm.nih.gov/pubmed/30678264
http://dx.doi.org/10.3390/nu11020240
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