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Regulation of c-Raf Stability through the CTLH Complex

c-Raf is a central component of the extracellular signal-regulated kinase (ERK) pathway which is implicated in the development of many cancer types. RanBPM (Ran-Binding Protein M) was previously shown to inhibit c-Raf expression, but how this is achieved remains unclear. RanBPM is part of a recently...

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Detalles Bibliográficos
Autores principales: McTavish, Christina J., Bérubé-Janzen, Wesley, Wang, Xu, Maitland, Matthew E. R., Salemi, Louisa M., Hess, David A., Schild-Poulter, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412545/
https://www.ncbi.nlm.nih.gov/pubmed/30795516
http://dx.doi.org/10.3390/ijms20040934