Cargando…
Regulation of c-Raf Stability through the CTLH Complex
c-Raf is a central component of the extracellular signal-regulated kinase (ERK) pathway which is implicated in the development of many cancer types. RanBPM (Ran-Binding Protein M) was previously shown to inhibit c-Raf expression, but how this is achieved remains unclear. RanBPM is part of a recently...
Autores principales: | McTavish, Christina J., Bérubé-Janzen, Wesley, Wang, Xu, Maitland, Matthew E. R., Salemi, Louisa M., Hess, David A., Schild-Poulter, Caroline |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412545/ https://www.ncbi.nlm.nih.gov/pubmed/30795516 http://dx.doi.org/10.3390/ijms20040934 |
Ejemplares similares
-
Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex
por: Salemi, Louisa M., et al.
Publicado: (2017) -
Structural and Functional Insights into GID/CTLH E3 Ligase Complexes
por: Maitland, Matthew E. R., et al.
Publicado: (2022) -
Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
por: Salemi, Louisa M., et al.
Publicado: (2017) -
Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis
por: Maitland, Matthew E. R., et al.
Publicado: (2021) -
The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation
por: Maitland, Matthew E. R., et al.
Publicado: (2019)