A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation

CRISPR-based technology has provided new avenues to interrogate gene function, but difficulties in transgene expression in post-mitotic neurons has delayed incorporation of these tools in the central nervous system (CNS). Here, we demonstrate a highly efficient, neuron-optimized dual lentiviral CRIS...

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Detalles Bibliográficos
Autores principales: Savell, Katherine E., Bach, Svitlana V., Zipperly, Morgan E., Revanna, Jasmin S., Goska, Nicholas A., Tuscher, Jennifer J., Duke, Corey G., Sultan, Faraz A., Burke, Julia N., Williams, Derek, Ianov, Lara, Day, Jeremy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Methods/New Tools
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412672/
https://www.ncbi.nlm.nih.gov/pubmed/30863790
http://dx.doi.org/10.1523/ENEURO.0495-18.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412672/
https://www.ncbi.nlm.nih.gov/pubmed/30863790
http://dx.doi.org/10.1523/ENEURO.0495-18.2019

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