IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling

The patho-mechanism leading to airway wall remodeling in allergic asthma is not well understood and remodeling is resistant to therapies. This study assessed the effect of immunoglobulin E (IgE) in the absence of allergens on human primary airway smooth muscle cell (ASMC) remodeling in vitro. ASMCs...

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Detalles Bibliográficos
Autores principales: Fang, Lei, Wang, Xinggang, Sun, Qingzhu, Papakonstantinou, Eleni, S’ng, Chongteck, Tamm, Michael, Stolz, Daiana, Roth, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412688/
https://www.ncbi.nlm.nih.gov/pubmed/30781615
http://dx.doi.org/10.3390/ijms20040875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412688/
https://www.ncbi.nlm.nih.gov/pubmed/30781615
http://dx.doi.org/10.3390/ijms20040875

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