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IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling
The patho-mechanism leading to airway wall remodeling in allergic asthma is not well understood and remodeling is resistant to therapies. This study assessed the effect of immunoglobulin E (IgE) in the absence of allergens on human primary airway smooth muscle cell (ASMC) remodeling in vitro. ASMCs...
Autores principales: | Fang, Lei, Wang, Xinggang, Sun, Qingzhu, Papakonstantinou, Eleni, S’ng, Chongteck, Tamm, Michael, Stolz, Daiana, Roth, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412688/ https://www.ncbi.nlm.nih.gov/pubmed/30781615 http://dx.doi.org/10.3390/ijms20040875 |
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