Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A

Following two orthogonal synthetic routes, a series of all four possible A-ring amino derivatives of the natural product Luotonin A (a known Topoisomerase I inhibitor) was synthesized. In both strategies, intramolecular cycloaddition reactions are the key step. The target compounds were obtained in...

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Detalles Bibliográficos
Autores principales: Ibric, Amra, Eckerstorfer, Stefan, Eder, Martin, Louko, Ivan, Tunjic, Leopold, Heffeter, Petra, Schueffl, Hemma Henrike, Marian, Brigitte, Haider, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412769/
https://www.ncbi.nlm.nih.gov/pubmed/30781470
http://dx.doi.org/10.3390/molecules24040716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412769/
https://www.ncbi.nlm.nih.gov/pubmed/30781470
http://dx.doi.org/10.3390/molecules24040716

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