Synthesis and Biological Evaluation of Novel Thiazolyl-Coumarin Derivatives as Potent Histone Deacetylase Inhibitors with Antifibrotic Activity

New histone deacetylases (HDAC) inhibitors with low toxicity to non-cancerous cells, are a prevalent issue at present because these enzymes are actively involved in fibrotic diseases. We designed and synthesized a novel series of thiazolyl-coumarins, substituted at position 6 (R = H, Br, OCH(3)), li...

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Detalles Bibliográficos
Autores principales: Pardo-Jiménez, Viviana, Navarrete-Encina, Patricio, Díaz-Araya, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412891/
https://www.ncbi.nlm.nih.gov/pubmed/30791388
http://dx.doi.org/10.3390/molecules24040739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412891/
https://www.ncbi.nlm.nih.gov/pubmed/30791388
http://dx.doi.org/10.3390/molecules24040739

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