Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-b]thiazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors

Based on the analysis of epidermal growth factor receptor (EGFR) complexes with gefitinib with molecular docking, the scaffold-hopping strategy, combination of the active substructures, and structural optimization of EGFR inhibitors, a novel series of benzo[4,5]imidazo[2,1-b]thiazole derivatives was...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Xinshan, Tan, Xiaoyu, An, Tiantian, Ma, Qingqing, Jin, Zhe, Wang, Ce, Meng, Qingguo, Hu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412895/
https://www.ncbi.nlm.nih.gov/pubmed/30769844
http://dx.doi.org/10.3390/molecules24040682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412895/
https://www.ncbi.nlm.nih.gov/pubmed/30769844
http://dx.doi.org/10.3390/molecules24040682

Ejemplares similares