A Validated HPLC-MS/MS Assay for 14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats

14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] mutilin (DPTM), a novel pleuromutilin candidate with a substituted pyrimidine moiety, has been confirmed to possess excellent antibacterial activity against Gram-positive bacteria. To illustrate the pharmacokinetic profile after intravenous (i.v.), intra...

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Detalles Bibliográficos
Autores principales: Fu, Yunxing, Liu, Yu, Yi, Yunpeng, Liang, Jianping, Wu, Qingfeng, Shang, Ruofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413085/
https://www.ncbi.nlm.nih.gov/pubmed/30813235
http://dx.doi.org/10.3390/molecules24040790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413085/
https://www.ncbi.nlm.nih.gov/pubmed/30813235
http://dx.doi.org/10.3390/molecules24040790

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