Circumventing senescence is associated with stem cell properties and metformin sensitivity

Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells, which are...

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Detalles Bibliográficos
Autores principales: Deschênes‐Simard, Xavier, Parisotto, Maxime, Rowell, Marie‐Camille, Le Calvé, Benjamin, Igelmann, Sebastian, Moineau‐Vallée, Karine, Saint‐Germain, Emmanuelle, Kalegari, Paloma, Bourdeau, Véronique, Kottakis, Filippos, Bardeesy, Nabeel, Ferbeyre, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413657/
https://www.ncbi.nlm.nih.gov/pubmed/30614183
http://dx.doi.org/10.1111/acel.12889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413657/
https://www.ncbi.nlm.nih.gov/pubmed/30614183
http://dx.doi.org/10.1111/acel.12889

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