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Circumventing senescence is associated with stem cell properties and metformin sensitivity
Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells, which are...
Autores principales: | Deschênes‐Simard, Xavier, Parisotto, Maxime, Rowell, Marie‐Camille, Le Calvé, Benjamin, Igelmann, Sebastian, Moineau‐Vallée, Karine, Saint‐Germain, Emmanuelle, Kalegari, Paloma, Bourdeau, Véronique, Kottakis, Filippos, Bardeesy, Nabeel, Ferbeyre, Gerardo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413657/ https://www.ncbi.nlm.nih.gov/pubmed/30614183 http://dx.doi.org/10.1111/acel.12889 |
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