ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway

PURPOSE: Chemotherapy after surgery can prolong the survival of patients with gliomas. Dimethylaminomicheliolide (DMAMCL), a novel chemotherapeutic agent, exhibited antitumor properties in acute myeloid leukemia stem cells and showed an increased drug concentration in the brain. This study aims to i...

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Detalles Bibliográficos
Autores principales: Wang, Yanjun, Zhang, Jiachen, Yang, Yihang, Liu, Qian, Xu, Guangming, Zhang, Rui, Pang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413739/
https://www.ncbi.nlm.nih.gov/pubmed/30881039
http://dx.doi.org/10.2147/OTT.S195329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413739/
https://www.ncbi.nlm.nih.gov/pubmed/30881039
http://dx.doi.org/10.2147/OTT.S195329

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