Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors that induce inflammation are not well understood. We previously identified a cell‐autonomous pathway through which damaged nuclear DNA is trafficked to the cytosol where it activates innate cytosolic DNA sen...

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Detalles Bibliográficos
Autores principales: Lan, Yuk Yuen, Heather, James M., Eisenhaure, Thomas, Garris, Christopher Stuart, Lieb, David, Raychowdhury, Raktima, Hacohen, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413746/
https://www.ncbi.nlm.nih.gov/pubmed/30706626
http://dx.doi.org/10.1111/acel.12901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413746/
https://www.ncbi.nlm.nih.gov/pubmed/30706626
http://dx.doi.org/10.1111/acel.12901

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