High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2

Persistent expression of high-risk HPV oncogenes is necessary for the development of anogenital and oropharyngeal cancers. Here, we show that E6/E7 expressing cells are hypersensitive to DNA crosslinking agent cisplatin and have defects in repairing DNA interstrand crosslinks (ICL). Importantly, we...

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Detalles Bibliográficos
Autores principales: Khanal, Sujita, Galloway, Denise A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413947/
https://www.ncbi.nlm.nih.gov/pubmed/30818369
http://dx.doi.org/10.1371/journal.ppat.1007442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413947/
https://www.ncbi.nlm.nih.gov/pubmed/30818369
http://dx.doi.org/10.1371/journal.ppat.1007442

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