Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substantially augment the benefits of mass drug administrat...

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Detalles Bibliográficos
Autores principales: von Geldern, Thomas W., Morton, Howard E., Clark, Rick F., Brown, Brian S., Johnston, Kelly L., Ford, Louise, Specht, Sabine, Carr, Robert A., Stolarik, Deanne F., Ma, Junli, Rieser, Matthew J., Struever, Dominique, Frohberger, Stefan J., Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D., Hübner, Marc P., Hoerauf, Achim, Taylor, Mark J., Ward, Stephen A., Marsh, Kennan, Kempf, Dale J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413952/
https://www.ncbi.nlm.nih.gov/pubmed/30818326
http://dx.doi.org/10.1371/journal.pntd.0007159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413952/
https://www.ncbi.nlm.nih.gov/pubmed/30818326
http://dx.doi.org/10.1371/journal.pntd.0007159

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