Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic proteins Bcl-XL and Bcl-2. These include the BH3 sequence...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Osterlund, Elizabeth J, Chi, Xiaoke, Pogmore, Justin, Leber, Brian, Andrews, David William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414199/
https://www.ncbi.nlm.nih.gov/pubmed/30860026
http://dx.doi.org/10.7554/eLife.37689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414199/
https://www.ncbi.nlm.nih.gov/pubmed/30860026
http://dx.doi.org/10.7554/eLife.37689

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