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Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic proteins Bcl-XL and Bcl-2. These include the BH3 sequence...
Autores principales: | Liu, Qian, Osterlund, Elizabeth J, Chi, Xiaoke, Pogmore, Justin, Leber, Brian, Andrews, David William |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414199/ https://www.ncbi.nlm.nih.gov/pubmed/30860026 http://dx.doi.org/10.7554/eLife.37689 |
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