Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca(2+)-dependent lipid scramblase, its regulation mechanism has remained elusive. Here, we have used cryo-electron microsc...

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Detalles Bibliográficos
Autores principales: Kalienkova, Valeria, Clerico Mosina, Vanessa, Bryner, Laura, Oostergetel, Gert T, Dutzler, Raimund, Paulino, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414200/
https://www.ncbi.nlm.nih.gov/pubmed/30785398
http://dx.doi.org/10.7554/eLife.44364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414200/
https://www.ncbi.nlm.nih.gov/pubmed/30785398
http://dx.doi.org/10.7554/eLife.44364

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