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Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca(2+)-dependent lipid scramblase, its regulation mechanism has remained elusive. Here, we have used cryo-electron microsc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414200/ https://www.ncbi.nlm.nih.gov/pubmed/30785398 http://dx.doi.org/10.7554/eLife.44364 |