Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we reveal features of murine TMEM16F (mTMEM16F) that u...

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Detalles Bibliográficos
Autores principales: Alvadia, Carolina, Lim, Novandy K, Clerico Mosina, Vanessa, Oostergetel, Gert T, Dutzler, Raimund, Paulino, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414204/
https://www.ncbi.nlm.nih.gov/pubmed/30785399
http://dx.doi.org/10.7554/eLife.44365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414204/
https://www.ncbi.nlm.nih.gov/pubmed/30785399
http://dx.doi.org/10.7554/eLife.44365

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