R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes

R-loops are three-stranded nucleic acid structures that form during transcription, especially over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells (mESCs), CpG-rich developmental regulator genes are repressed by the Polycomb complexes PRC1 and PRC2. Here, we show that...

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Detalles Bibliográficos
Autores principales: Skourti-Stathaki, Konstantina, Torlai Triglia, Elena, Warburton, Marie, Voigt, Philipp, Bird, Adrian, Pombo, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414425/
https://www.ncbi.nlm.nih.gov/pubmed/30709709
http://dx.doi.org/10.1016/j.molcel.2018.12.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414425/
https://www.ncbi.nlm.nih.gov/pubmed/30709709
http://dx.doi.org/10.1016/j.molcel.2018.12.016

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