Plasma alpha‐synuclein detected by single molecule array is increased in PD

We utilized ultrasensitive single molecule technology to measure plasma alpha‐synuclein in 221 subjects (51 controls, 170 PD). Plasma alpha‐synuclein levels were significantly higher in PD than controls (15506.3 vs. 13057.0 pg/mL, P = 0.037), adjusting for age and gender. In PD, alpha‐synuclein leve...

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Autores principales: Ng, Adeline S. L., Tan, Yi Jayne, Lu, Zhonghao, Ng, Ebonne Y. L., Ng, Samuel Y. E., Chia, Nicole S. Y., Setiawan, Fiona, Xu, Zheyu, Tay, Kay Yaw, Prakash, Kumar M., Au, Wing Lok, Tan, Eng‐King, Tan, Louis C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414476/
https://www.ncbi.nlm.nih.gov/pubmed/30911585
http://dx.doi.org/10.1002/acn3.729
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author Ng, Adeline S. L.
Tan, Yi Jayne
Lu, Zhonghao
Ng, Ebonne Y. L.
Ng, Samuel Y. E.
Chia, Nicole S. Y.
Setiawan, Fiona
Xu, Zheyu
Tay, Kay Yaw
Prakash, Kumar M.
Au, Wing Lok
Tan, Eng‐King
Tan, Louis C. S.
author_facet Ng, Adeline S. L.
Tan, Yi Jayne
Lu, Zhonghao
Ng, Ebonne Y. L.
Ng, Samuel Y. E.
Chia, Nicole S. Y.
Setiawan, Fiona
Xu, Zheyu
Tay, Kay Yaw
Prakash, Kumar M.
Au, Wing Lok
Tan, Eng‐King
Tan, Louis C. S.
author_sort Ng, Adeline S. L.
collection PubMed
description We utilized ultrasensitive single molecule technology to measure plasma alpha‐synuclein in 221 subjects (51 controls, 170 PD). Plasma alpha‐synuclein levels were significantly higher in PD than controls (15506.3 vs. 13057.0 pg/mL, P = 0.037), adjusting for age and gender. In PD, alpha‐synuclein levels did not vary by H&Y stage or UPDRS motor scores but were significantly higher in PD patients with poorer cognition (MMSE ≤ 25) than controls (P = 0.016, Bonferroni corrected P = 0.047). Alpha‐synuclein levels quantified using ultrasensitive single molecule technology discriminate PD from controls and correlate with cognitive severity. These preliminary findings require independent validation to determine the utility of this assay.
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spelling pubmed-64144762019-03-25 Plasma alpha‐synuclein detected by single molecule array is increased in PD Ng, Adeline S. L. Tan, Yi Jayne Lu, Zhonghao Ng, Ebonne Y. L. Ng, Samuel Y. E. Chia, Nicole S. Y. Setiawan, Fiona Xu, Zheyu Tay, Kay Yaw Prakash, Kumar M. Au, Wing Lok Tan, Eng‐King Tan, Louis C. S. Ann Clin Transl Neurol Brief Communications We utilized ultrasensitive single molecule technology to measure plasma alpha‐synuclein in 221 subjects (51 controls, 170 PD). Plasma alpha‐synuclein levels were significantly higher in PD than controls (15506.3 vs. 13057.0 pg/mL, P = 0.037), adjusting for age and gender. In PD, alpha‐synuclein levels did not vary by H&Y stage or UPDRS motor scores but were significantly higher in PD patients with poorer cognition (MMSE ≤ 25) than controls (P = 0.016, Bonferroni corrected P = 0.047). Alpha‐synuclein levels quantified using ultrasensitive single molecule technology discriminate PD from controls and correlate with cognitive severity. These preliminary findings require independent validation to determine the utility of this assay. John Wiley and Sons Inc. 2019-02-15 /pmc/articles/PMC6414476/ /pubmed/30911585 http://dx.doi.org/10.1002/acn3.729 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Ng, Adeline S. L.
Tan, Yi Jayne
Lu, Zhonghao
Ng, Ebonne Y. L.
Ng, Samuel Y. E.
Chia, Nicole S. Y.
Setiawan, Fiona
Xu, Zheyu
Tay, Kay Yaw
Prakash, Kumar M.
Au, Wing Lok
Tan, Eng‐King
Tan, Louis C. S.
Plasma alpha‐synuclein detected by single molecule array is increased in PD
title Plasma alpha‐synuclein detected by single molecule array is increased in PD
title_full Plasma alpha‐synuclein detected by single molecule array is increased in PD
title_fullStr Plasma alpha‐synuclein detected by single molecule array is increased in PD
title_full_unstemmed Plasma alpha‐synuclein detected by single molecule array is increased in PD
title_short Plasma alpha‐synuclein detected by single molecule array is increased in PD
title_sort plasma alpha‐synuclein detected by single molecule array is increased in pd
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414476/
https://www.ncbi.nlm.nih.gov/pubmed/30911585
http://dx.doi.org/10.1002/acn3.729
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