Anti‐PrP(C) antibody rescues cognition and synapses in transgenic alzheimer mice

OBJECTIVE: Amyloid‐beta oligomers (Aßo) trigger the development of Alzheimer's disease (AD) pathophysiology. Cellular prion protein (PrPC) initiates synaptic damage as a high affinity receptor for Aßo. Here, we evaluated the preclinical therapeutic efficacy of a fully human monoclonal antibody...

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Detalles Bibliográficos
Autores principales: Cox, Timothy O., Gunther, Erik C., Brody, A. Harrison, Chiasseu, Marius T., Stoner, Austin, Smith, Levi M., Haas, Laura T., Hammersley, Jayne, Rees, Gareth, Dosanjh, Bhupinder, Groves, Maria, Gardener, Matthew, Dobson, Claire, Vaughan, Tristan, Chessell, Iain, Billinton, Andrew, Strittmatter, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414488/
https://www.ncbi.nlm.nih.gov/pubmed/30911579
http://dx.doi.org/10.1002/acn3.730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414488/
https://www.ncbi.nlm.nih.gov/pubmed/30911579
http://dx.doi.org/10.1002/acn3.730

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