Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methylene-tetrahydrofolate (THF) to 5-methyl-THF, thereby committing one-carbon units to the methionine cycle. While MTHFR has long been known to be allosterically inhibited by S-adenosylmethionine (SAM), only...

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Detalles Bibliográficos
Autores principales: Zheng, Yuxiang, Ramsamooj, Shivan, Li, Qian, Johnson, Jared L., Yaron, Tomer M., Sharra, Klaus, Cantley, Lewis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414673/
https://www.ncbi.nlm.nih.gov/pubmed/30862944
http://dx.doi.org/10.1038/s41598-019-40950-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414673/
https://www.ncbi.nlm.nih.gov/pubmed/30862944
http://dx.doi.org/10.1038/s41598-019-40950-7

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