Cargando…

Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methylene-tetrahydrofolate (THF) to 5-methyl-THF, thereby committing one-carbon units to the methionine cycle. While MTHFR has long been known to be allosterically inhibited by S-adenosylmethionine (SAM), only...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Yuxiang, Ramsamooj, Shivan, Li, Qian, Johnson, Jared L., Yaron, Tomer M., Sharra, Klaus, Cantley, Lewis C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414673/ https://www.ncbi.nlm.nih.gov/pubmed/30862944 http://dx.doi.org/10.1038/s41598-019-40950-7

Ejemplares similares

The Polymorphisms in Methylenetetrahydrofolate Reductase, Methionine Synthase, Methionine Synthase Reductase, and the Risk of Colorectal Cancer
por: Zhou, Daijun, et al.
Publicado: (2012)

Serum Folate and Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism Adjusted for Folate Intake
por: Nishio, Kazuko, et al.
Publicado: (2008)

Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines
por: Sekhon, J, et al.
Publicado: (2002)

Folate Metabolism Gene 5,10-Methylenetetrahydrofolate Reductase (MTHFR) Is Associated with ADHD in Myelomeningocele Patients
por: Spellicy, Catherine J., et al.
Publicado: (2012)

Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia
por: Chen, Chun-Hsin, et al.
Publicado: (2021)

Evaluation of methylenetetrahydrofolate reductase and S-adenosyl-methionine level in male infertility: A case-control study
por: Baranizadeh, Khadijeh, et al.
Publicado: (2022)

Toward a better understanding of folate metabolism in health and disease
por: Zheng, Yuxiang, et al.
Publicado: (2019)

Folate Intake and Methylenetetrahydrofolate Reductase Gene Polymorphisms as Predictive and Prognostic Biomarkers for Ovarian Cancer Risk
por: Zhang, Li, et al.
Publicado: (2012)

Methylenetetrahydrofolate reductase and psychiatric diseases
por: Wan, Lin, et al.
Publicado: (2018)

Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study
por: Gil-Prieto, Ruth, et al.
Publicado: (2009)

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
por: Froese, D. Sean, et al.
Publicado: (2018)

Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome
por: Turgal, Mert, et al.
Publicado: (2018)

Methylenetetrahydrofolate Reductase C677T Gene Variant in Relation to Body Mass Index and Folate Concentration in a Polish Population
por: Wrzosek, Małgorzata, et al.
Publicado: (2022)

Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer
por: Campbell, Ian G, et al.
Publicado: (2002)

Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia
por: KÜPELİ, Serhan
Publicado: (2015)

Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism: influence on prostate cancer risk and interactions
por: Kobayashi, Lindsay C., et al.
Publicado: (2012)

Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse
por: Oien, Derek B., et al.
Publicado: (2011)

Relationship between methylenetetrahydrofolate reductase gene polymorphisms and methotrexate drug metabolism and toxicity
por: Tan, Yinli, et al.
Publicado: (2023)

Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China
por: Chen, Min, et al.
Publicado: (2008)

Prognostic Relevance of Methylenetetrahydrofolate Reductase Polymorphisms for Prostate Cancer
por: Lin, Victor C., et al.
Publicado: (2016)

Methylenetetrahydrofolate Reductase Polymorphism and Premature Coronary Artery Disease
por: Zaghloul, Ahmed, et al.
Publicado: (2019)

Clinical presentation of seven patients with Methylenetetrahydrofolate reductase deficiency
por: Aljassim, Nada, et al.
Publicado: (2020)

Erratum to “Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse”
por: Oien, Derek B., et al.
Publicado: (2012)

Methylenetetrahydrofolate Reductase A1298C Polymorphism and Major Depressive Disorder
por: Cho, Kevin, et al.
Publicado: (2017)

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathy
por: Jongbloet, Piet Hein, et al.
Publicado: (2008)

Effect of folate status and methylenetetrahydrofolate reductase genotypes on the complications and outcome of high dose methotrexate chemotherapy in north Indian children with acute lymphoblastic leukemia
por: Moulik, Nirmalya Roy, et al.
Publicado: (2016)

Maternal Supplementary Folate Intake, Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms and the Risk of Orofacial Cleft in Iranian Children
por: Ebadifar, Asghar, et al.
Publicado: (2015)

Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer
por: Ferrari, Ariana, et al.
Publicado: (2019)

The Association of Methylenetetrahydrofolate Reductase Genotypes with the Risk of Childhood Leukemia in Taiwan
por: Pei, Jen-Sheng, et al.
Publicado: (2015)

Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Infant’s Anthropometry at Birth
por: Aguilar-Lacasaña, Sofía, et al.
Publicado: (2021)

Methionine Sulfoxide Reductases of Archaea
por: Maupin-Furlow, Julie A.
Publicado: (2018)

Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses
por: Kastenhuber, Edward R., et al.
Publicado: (2022)

Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head
por: Chai, Wei, et al.
Publicado: (2015)

Four families of folate-independent methionine synthases
por: Price, Morgan N., et al.
Publicado: (2021)

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region
por: Raina, Jyotdeep K., et al.
Publicado: (2016)

Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice
por: Sontag, Jean-Marie, et al.
Publicado: (2014)

Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
por: Kweon, Sun-Seog, et al.
Publicado: (2014)

Methylenetetrahydrofolate Reductase Gene Polymorphisms in Children with Attention Deficit Hyperactivity Disorder
por: Gokcen, Cem, et al.
Publicado: (2011)

Methylenetetrahydrofolate reductase homozygous mutation in a young boy with cerebellar infarction
por: Spalice, Alberto, et al.
Publicado: (2009)

Prevalence of methylenetetrahydrofolate reductase C677T polymorphism in eastern Uttar Pradesh
por: Rai, Vandana, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tb953lq5hlpa1p5h11dne5ae75