Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket

HIV-1 capsid protein (CA) plays critical roles in both early and late stages of the viral replication cycle. Mutagenesis and structural experiments have revealed that capsid core stability significantly affects uncoating and initiation of reverse transcription in host cells. This has led to efforts...

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Detalles Bibliográficos
Autores principales: Craveur, Pierrick, Gres, Anna T., Kirby, Karen A., Liu, Dandan, Hammond, John A., Deng, Yisong, Forli, Stefano, Goodsell, David S., Williamson, James R., Sarafianos, Stefan G., Olson, Arthur J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414707/
https://www.ncbi.nlm.nih.gov/pubmed/30862755
http://dx.doi.org/10.1128/mBio.02858-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414707/
https://www.ncbi.nlm.nih.gov/pubmed/30862755
http://dx.doi.org/10.1128/mBio.02858-18

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