Targeting Oxidative Stress With Auranofin or Prima-1(Met) to Circumvent p53 or Bax/Bak Deficiency in Myeloma Cells

Prima-1(Met) (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53. Because this ROS induction was, at least in part, due to a direct interference with the thioredoxin reductase enzyme, we investigated whether activ...

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Detalles Bibliográficos
Autores principales: Tessoulin, Benoit, Descamps, Geraldine, Dousset, Christelle, Amiot, Martine, Pellat-Deceunynck, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414792/
https://www.ncbi.nlm.nih.gov/pubmed/30895171
http://dx.doi.org/10.3389/fonc.2019.00128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414792/
https://www.ncbi.nlm.nih.gov/pubmed/30895171
http://dx.doi.org/10.3389/fonc.2019.00128

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