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Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress i...

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Autores principales: Flis, Sylwia, Chojnacki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415732/
https://www.ncbi.nlm.nih.gov/pubmed/30880916
http://dx.doi.org/10.2147/DDDT.S191303
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author Flis, Sylwia
Chojnacki, Tomasz
author_facet Flis, Sylwia
Chojnacki, Tomasz
author_sort Flis, Sylwia
collection PubMed
description Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress in the understanding of the molecular etiology of CML and the development of novel therapeutic strategies, clinicians still face many challenges in the effective treatment of patients. In this review, we discuss the pathways of diagnosis and treatment of patients, as well as the problems appearing in the course of disease development. We also briefly refer to several aspects regarding the current knowledge on the molecular basis of CML and new potential therapeutic targets.
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spelling pubmed-64157322019-03-16 Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities Flis, Sylwia Chojnacki, Tomasz Drug Des Devel Ther Review Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress in the understanding of the molecular etiology of CML and the development of novel therapeutic strategies, clinicians still face many challenges in the effective treatment of patients. In this review, we discuss the pathways of diagnosis and treatment of patients, as well as the problems appearing in the course of disease development. We also briefly refer to several aspects regarding the current knowledge on the molecular basis of CML and new potential therapeutic targets. Dove Medical Press 2019-03-08 /pmc/articles/PMC6415732/ /pubmed/30880916 http://dx.doi.org/10.2147/DDDT.S191303 Text en © 2019 Flis and Chojnacki. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Flis, Sylwia
Chojnacki, Tomasz
Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
title Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
title_full Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
title_fullStr Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
title_full_unstemmed Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
title_short Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
title_sort chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415732/
https://www.ncbi.nlm.nih.gov/pubmed/30880916
http://dx.doi.org/10.2147/DDDT.S191303
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