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Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415732/ https://www.ncbi.nlm.nih.gov/pubmed/30880916 http://dx.doi.org/10.2147/DDDT.S191303 |
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author | Flis, Sylwia Chojnacki, Tomasz |
author_facet | Flis, Sylwia Chojnacki, Tomasz |
author_sort | Flis, Sylwia |
collection | PubMed |
description | Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress in the understanding of the molecular etiology of CML and the development of novel therapeutic strategies, clinicians still face many challenges in the effective treatment of patients. In this review, we discuss the pathways of diagnosis and treatment of patients, as well as the problems appearing in the course of disease development. We also briefly refer to several aspects regarding the current knowledge on the molecular basis of CML and new potential therapeutic targets. |
format | Online Article Text |
id | pubmed-6415732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-64157322019-03-16 Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities Flis, Sylwia Chojnacki, Tomasz Drug Des Devel Ther Review Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. At the molecular level, the disorder results from t(9;22)(q34;q11) reciprocal translocation between chromosomes, which leads to the formation of an oncogenic BCR–ABL gene fusion. Instead of progress in the understanding of the molecular etiology of CML and the development of novel therapeutic strategies, clinicians still face many challenges in the effective treatment of patients. In this review, we discuss the pathways of diagnosis and treatment of patients, as well as the problems appearing in the course of disease development. We also briefly refer to several aspects regarding the current knowledge on the molecular basis of CML and new potential therapeutic targets. Dove Medical Press 2019-03-08 /pmc/articles/PMC6415732/ /pubmed/30880916 http://dx.doi.org/10.2147/DDDT.S191303 Text en © 2019 Flis and Chojnacki. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Flis, Sylwia Chojnacki, Tomasz Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
title | Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
title_full | Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
title_fullStr | Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
title_full_unstemmed | Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
title_short | Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
title_sort | chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415732/ https://www.ncbi.nlm.nih.gov/pubmed/30880916 http://dx.doi.org/10.2147/DDDT.S191303 |
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