The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine

Elevated plasma concentrations of the uremic toxin asymmetrical dimethylarginine (ADMA) and low plasma concentrations of L-homoarginine are independently associated with cardiovascular events and total mortality. Enzymes degrading ADMA [dimethylaminohydrolase 1 (DDAH1)] and synthesizing L-homoargini...

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Detalles Bibliográficos
Autores principales: Taghikhani, Emir, Maas, Renke, Fromm, Martin F., König, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415861/
https://www.ncbi.nlm.nih.gov/pubmed/30865704
http://dx.doi.org/10.1371/journal.pone.0213747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415861/
https://www.ncbi.nlm.nih.gov/pubmed/30865704
http://dx.doi.org/10.1371/journal.pone.0213747

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