Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR

Ras-related C3 botulinum toxin substrate 1 (Rac1) plays critical roles in the maintenance of cell morphology by cycling between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states. Rac1 P29S mutant is known to strongly promote oncogenesis by facilitating i...

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Detalles Bibliográficos
Autores principales: Toyama, Yuki, Kontani, Kenji, Katada, Toshiaki, Shimada, Ichio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415961/
https://www.ncbi.nlm.nih.gov/pubmed/30891502
http://dx.doi.org/10.1126/sciadv.aav8945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415961/
https://www.ncbi.nlm.nih.gov/pubmed/30891502
http://dx.doi.org/10.1126/sciadv.aav8945

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