Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1

Successful mitosis requires that cyclin B1:CDK1 kinase activity remains high until chromosomes are correctly aligned on the mitotic spindle. It has therefore been unclear why, in mammalian oocyte meiosis, cyclin B1 destruction begins before chromosome alignment is complete. Here, we resolve this par...

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Detalles Bibliográficos
Autores principales: Levasseur, Mark D., Thomas, Christopher, Davies, Owen R., Higgins, Jonathan M.G., Madgwick, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416240/
https://www.ncbi.nlm.nih.gov/pubmed/30745144
http://dx.doi.org/10.1016/j.devcel.2019.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416240/
https://www.ncbi.nlm.nih.gov/pubmed/30745144
http://dx.doi.org/10.1016/j.devcel.2019.01.008

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