Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

The Polycomb group (PcG) protein family is a well-known group of epigenetic modifiers. We used zebrafish to investigate the role of Rnf2, the enzymatic subunit of PRC1. We found a positive correlation between loss of Rnf2 and upregulation of genes, especially of those whose promoter is normally boun...

Descripción completa

Detalles Bibliográficos
Autores principales: Chrispijn, Naomi D., Elurbe, Dei M., Mickoleit, Michaela, Aben, Marco, de Bakker, Dennis E.M., Andralojc, Karolina M., Huisken, Jan, Bakkers, Jeroen, Kamminga, Leonie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416260/
https://www.ncbi.nlm.nih.gov/pubmed/30867528
http://dx.doi.org/10.1038/s41598-019-40867-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416260/
https://www.ncbi.nlm.nih.gov/pubmed/30867528
http://dx.doi.org/10.1038/s41598-019-40867-1

Ejemplares similares